Sirolimus therapy following subtotal pancreatectomy in neonatal hyperinsulinemic hypoglycaemia: a case report
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چکیده
منابع مشابه
Sirolimus therapy following subtotal pancreatectomy in neonatal hyperinsulinemic hypoglycaemia: a case report
Hyperinsulinemic hypoglycaemia (HH) occurs due to an unregulated insulin production from the pancreatic b-cells in the presence of low blood glucose. Mutations in ABCC8 and KCNJ11 are associated with severe HH that is unresponsive to conventional medical treatment. The only treatment for patients with medically unresponsive diffuse HH is a subtotal pancreatectomy. However, following surgery, hy...
متن کاملLaparascopic subtotal pancreatectomy in persistent hyperinsulinemic hypoglycemia of infancy
Two and half-year old Saudi boy was diagnosed with persistent hyperinsulinemic hypoglycemia of infancy (PHHI). He was initially managed with diazoxide and octreotide, however he was medical therapy unresponsive. Surgical intervention was recommended and he had laparoscopic subtotal pancreatectomy. This is the first reported Saudi case of PHHI who was managed surgically using the laparoscopic te...
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Hyperinsulinemic hypoglycemia (HH) is one of the most common causes of persistent hypoglycemic episodes in neonates. Current pharmacologic treatment of neonatal HH includes diazoxide and octreotide, whereas for diffuse, unresponsive cases a subtotal pancreatectomy may be the last resort, with questionable efficacy. Here we report a case of congenital diffuse neonatal HH, first suspected when se...
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ژورنال
عنوان ژورنال: International Journal of Pediatric Endocrinology
سال: 2015
ISSN: 1687-9856
DOI: 10.1186/1687-9856-2015-s1-p81